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PHOSPHORYLATION/DEPHOSPHORYLATION OF PROTEINS AS ONE OF THE MAIN MECHANISMS OF FINE REGULATION OF METABOLIC FUNCTIONS OF MITOCHONDRIA
Original title
ФОСФОРИЛИРОВАНИЕ/ДЕФОСФОРИЛИРОВАНИЕ БЕЛКОВ КАК ОДИН ИЗ ВЕДУЩИХ МЕХАНИЗМОВ ТОНКОЙ РЕГУЛЯЦИИ МЕТАБОЛИЧЕСКИХ ФУНКЦИЙ МИТОХОНДРИЙ
Authors
I.Y. Subota, M.V. Kulinchenko, Yu.M. Konstantinov
Contact information
Siberian Institute of Plant Physiology and Biochemistry of Siberian Branch of Russian Academy of Sciences, Irkutsk, Russia, Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.
Pages
993-997
DOI
10.31255/978-5-94797-319-8-993-997
Abstract
Reversible covalent modification of proteins, such as phosphorylation/dephosphorylation and thiol-disulfide exchange, has an essential role in the fine metabolic regulation of enzymes. Modification of enzymes is very sensitive to signals, in mitochondria Ca2+ions play an important signaling role. The level of phosphorylation of mitochondrial proteins in the presence of Ca2+, causing the opening of the CSA-sensitive mPTP-pore, and of mitochondrial respiratory complexes by separation of protein subunits in 2D BN/SDS-PAGE electrophoresis was studied.