СHARACTERISTICS OF ANTIGEN-ANTIBODY CROSS-REACTIVITY BETWEEN DIFFERENT TYPES OF HUMAN PAPILLOMAVIRUS (HPV) DURING PLANT NUCLEAR GENETIC TRANSFORMATION

Original title

ОСОБЕННОСТИ АНТИГЕН-АНТИТЕЛЬНОГО ВЗАИМОДЕЙСТВИЯ У РАЗЛИЧНЫХ ТИПОВ ВИРУСА ПАПИЛЛОМЫ ЧЕЛОВЕКА (ВПЧ) ПРИ ЯДЕРНОЙ ГЕНЕТИЧЕСКОЙ ТРАНСФОРМАЦИИ РАСТЕНИЙ

Authors

R.K.Salyaev, N.I.Rekoslavskaya, A.S. Stolbikov

Contact information

Siberian institute of plant physiology and biochemistry SB RAS, Irkutsk

Irkutsk Scientific center SB RAS

Pages

114-116

DOI

10.31255/978-5-94797-318-1-114-116

Abstract

The analysis of the properties of quadrivalent peroral vaccine against the cervical cancer, which was created in plant expression system on the base of transgenic tomato fruits, by immunoassay and Western blot hybridization showed that antibodies against human papilloma virus 16 L1 (HPV16 L1) actively interacted not only with the antigenic proteins HPV16 L1, HPV18 L1, HPV31 L1 and HPV45 L1, but also with the antigenic protein HPV6 L1, which belongs to another HPV family. Thus, new data on the possibility of cross-reactivity between antibodies and antigens belonging to remote HPV families were obtained.