STUDY OF ARABIDOPSIS MITOCHONDRIAL MEMBRANE PROTEINS ROLE IN DNA IMPORT

Original title

ИЗУЧЕНИЕ РОЛИ МЕМБРАННЫХ БЕЛКОВ МИТОХОНДРИЙ АРАБИДОПСИСА В ИМПОРТЕ ДНК

Authors

Bolotova T.A., Tarasenko V.I., Konstantinov Y.M., Koulintchenko M.V.

Contact information

Siberian Institute of Plant Physiology and Biochemistry SB RAS, Irkutsk, Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.

Pages

14-16

DOI

10.31255/978-5-94797-318-1-14-16

Abstract

Mitochondria require the import of proteins and nucleic acids to carry out their functions in the cell. Import of tRNA is essential for gene expression and its regulation in the mitochondria of plants, whereas mitochondrial competence for the DNA uptake is likely to contribute to its genome dynamics and evolution. Protein apparatus of the tRNA import in plants is well studied at the level of the outer mitochondrial membrane. VDAC (Voltage-Dependent Anion Channel), an important protein-carrier of negatively charged metabolites across the mitochondrial membrane, was shown to be the main transport channel for the tRNA import in plant mitochondria. The role of this transporter was also established for the DNA import into mitochondria of different organisms. However, unlike the tRNA import, the participation of other membrane proteins of the outer membrane, which could determine the specificity of transport of the DNA molecules of different length and structure in the mitochondria, is still not found. The aim of this work is to study the involvement of proteins of the outer mitochondrial membrane, namely VDAC1 and VDAC3 isoforms, CuBP and TSPO, in the DNA import mechanism.